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生化制药厂的老板Franklin提供大量资金供让Susan McAlester博士研究抗老年痴呆症的药物。Susan和研究小组在设备精良的海底研究中心，提取鲨鱼脑中蛋白质，注入坏死的人类脑细胞。为了可以提取到更多的鲨鱼脑蛋白，Susan也同时加大了鲨鱼们的脑容量。这一举动让本来作为试验品的鲨鱼们变得更为强壮和聪明。鲨鱼专家Carter因和鲨鱼们朝夕相处时发现了鲨鱼们的异样，并向Susan提出了警告，却得到了Susan的无视。终于，在最后一次实验中，那些曾经沦为人类试验品的凶残鲨鱼们向人类展开报复……。New DCI John Barnaby arrives in Midsomer and is bemused by the quaint villages and their quirky residents. But when a local DJ is crushed to death at a traditional girls’ boarding school, he soon discovers that murder and deception are never far away. As the death toll rises, could Barnaby’s first case also be his last?。